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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN18
All Species:
23.33
Human Site:
S203
Identified Species:
57.04
UniProt:
Q99952
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99952
NP_055184.2
460
50482
S203
P
D
R
G
V
P
S
S
P
D
H
M
L
A
M
Chimpanzee
Pan troglodytes
XP_513663
807
91678
S201
P
D
H
D
V
P
S
S
I
D
P
I
L
E
L
Rhesus Macaque
Macaca mulatta
XP_001093333
456
50339
S203
P
D
R
G
V
P
S
S
P
D
H
M
L
A
M
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q61152
453
50183
S203
P
D
H
G
V
P
S
S
S
D
H
I
L
T
M
Rat
Rattus norvegicus
NP_001013129
453
50088
S203
P
D
H
G
V
P
S
S
S
D
H
I
L
T
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521024
682
72925
N372
P
D
R
G
I
P
D
N
T
G
H
F
L
S
M
Chicken
Gallus gallus
XP_001235234
775
85980
S201
P
D
H
D
I
P
S
S
I
D
P
I
L
E
L
Frog
Xenopus laevis
NP_001121240
511
57423
S204
P
D
H
G
I
P
D
S
Y
S
C
F
L
E
M
Zebra Danio
Brachydanio rerio
NP_001013470
513
57261
M203
P
D
H
G
I
P
D
M
P
D
G
I
L
G
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
S207
P
D
H
G
V
P
T
S
V
K
P
I
L
D
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.1
94.7
N.A.
N.A.
75.8
74.7
N.A.
36.5
27.6
42.2
39.1
N.A.
N.A.
N.A.
N.A.
22.6
Protein Similarity:
100
38.7
96.5
N.A.
N.A.
82.6
82.3
N.A.
46.9
40.6
58.7
55.3
N.A.
N.A.
N.A.
N.A.
32.4
P-Site Identity:
100
53.3
100
N.A.
N.A.
73.3
73.3
N.A.
53.3
46.6
46.6
53.3
N.A.
N.A.
N.A.
N.A.
53.3
P-Site Similarity:
100
66.6
100
N.A.
N.A.
80
80
N.A.
73.3
66.6
53.3
66.6
N.A.
N.A.
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
20
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
0
100
0
20
0
0
30
0
0
70
0
0
0
10
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
30
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
20
0
0
0
% F
% Gly:
0
0
0
80
0
0
0
0
0
10
10
0
0
10
0
% G
% His:
0
0
70
0
0
0
0
0
0
0
50
0
0
0
0
% H
% Ile:
0
0
0
0
40
0
0
0
20
0
0
60
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
100
0
20
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
20
0
0
80
% M
% Asn:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
100
0
0
0
0
100
0
0
30
0
30
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
30
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
60
80
20
10
0
0
0
10
0
% S
% Thr:
0
0
0
0
0
0
10
0
10
0
0
0
0
20
0
% T
% Val:
0
0
0
0
60
0
0
0
10
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _